As a result, Msi3 may represent a favorable target for designing novel and effective therapeutics with fewer side effects for candidiasis. Moreover, the sequence conservation between human and fungal Hsp110s is relatively low (<40% identity). In contrast, Hsp110s are not essential for mammals under normal conditions, as suggested by knockout experiments using mice 23, 24, 25. albicans, and it is essential for the survival, growth, and infection of C. Thus, efficient therapeutic options with novel modes of action are needed urgently for treating this dangerous pathogen.ġ10 kDa Heat Shock Proteins (Hsp110s) are found in the cytosol of eukaryotes and play essential roles in maintaining cellular protein homeostasis (proteostasis) 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Moreover, the treatment has been further complicated by a dramatic rise in resistance to these available antifungal drugs 8, 9, 10. However, only three classes of antifungal drugs targeting two unique pathways (sterol ergosterol and the cell wall) are available to treat candidiasis 8, 9, 10. albicans is typically commensal for healthy people 3, 4, it is one of the leading causes of hospital-acquired infections and can cause serious infections for critically ill or immunocompromised individuals, such as patients with AIDS, cancers, organ transplants, or implants 5, 6, 7. C andida albicans is an opportunistic pathogen that can cause various fungal infections (candidiasis), ranging from oral thrush to candidemia, one of the most prevailing disseminated bloodstream infections (with a mortality rate of over 40%) 1, 2.
0 kommentar(er)
